VS2015 redists are not part of our standard redist install (because their update prereqs on Windows 7 and 8 make them virtually impossible to package in), so applocal install is required.
Start QAGame in editor.
Package for Win64.
Install package on a clean (no redists) machine.
Run the game.
Game will crash asking for access to a redist DLL.
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-33903 in the post.