When using Application Scale in the editor, using F11 to make the viewport fullscreen results in an either zoomed in or zoomed out fullscreen version.
Note: This same issue occurs when using a combination of UI scaling in windows 10 and "-enablehighdpi"
Regression?: No
This also occurred in 4.13
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There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-40461 in the post.