When using Actor to Lookat and adding a keyframe to the track, the references are lost to the selected Actor when saving the Sequence. This prevents the Sequence from being saved and generates a few errors.
This was reported and tested in 4.22 (CL-5660361). This was reproduced in Main 4.23 (CL-5683886). This issue was not present in 4.21 but that was before the overhaul to Sequencer.
Results: The chain of references are lost and the sequence can't be saved
Expected: The sequence saves without error
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-72210 in the post.