Multiple vendor's asked if there could be a way to programmatically set the created OCIO config for a viewport and select the source/dest settings as well and enable/disable the config.
The current workflow is to set the Config through the Show > OCIO Display Menu.
New utility provided via editor blueprints:
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-183849 in the post.