Enabling the "Force all skinned meshes to recompute tangents" sets the value at a Windows user level so that it affects all UE4 projects opened by that user, including unrelated packaged projects. The setting is stored in a "UserEngine.ini" file located in C:\Users\<Windows user name>\AppData\Local\Unreal Engine\Engine\Config.
This could potentially prevent anyone (not just a UE4 developer) who happens to have that .ini file with the setting enabled from being able to run any packaged UE4 project (including games purchased from Steam) that do not include the shaders required by the setting.
The project fails to run successfully, and shows an error that states Missing global shader FRecomputeTangentsPerVertexPassCS, Please make sure cooking was successful (message shown from Main, CL 4009371).
The project runs successfully.
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-58013 in the post.