The Compile Single File option in UnrealVS fails if the Engine is located in a directory where there is a space somewhere in the path to the Engine's root directory.
This requires that the Engine be installed in a location where there is a space in a folder name (eg. D:\Test Installation\UnrealEngine)
The build fails with an error similar to 'D:\Test' is not recognized as an internal or external command, operable program or batch file.
The build completes successfully.
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-64752 in the post.