The Compile Single File option in UnrealVS fails if the Engine is located in a directory where there is a space somewhere in the path to the Engine's root directory.
This requires that the Engine be installed in a location where there is a space in a folder name (eg. D:\Test Installation\UnrealEngine)
The build fails with an error similar to 'D:\Test' is not recognized as an internal or external command, operable program or batch file.
The build completes successfully.
There's no existing public thread on this issue, so head over toAnswerHub just mention UE-64752 in the post.