In 4.21.1 it is no longer possible to perform a Hot Reload when the game is open in the Editor and using the DebugGame Editor configuration.
Yes. A Hot Reload was possible in 4.20.3 when using the DebugGame Editor configuration
The build fails with a message similar to the following: 2>LINK : fatal error LNK1104: cannot open file 'D:\Unreal Projects\Current Issues\TestDebug2\Binaries\Win64\UE4Editor-TestDebug2-Win64-DebugGame.dll'
The build completes successfully and a Hot Reload is performed to update the project in the Editor.
Close the Editor and perform a normal non-Hot Reload build in Visual Studio.
There's no existing public thread on this issue, so head over toAnswerHub just mention UE-67911 in the post.