Regression as of 4.22.
When creating more than one layer in a Paper2DTilemapAsset, the tiles will not render correctly in the second layer. Please see the attached gif for an example.
Result: Rendering of painted tilemaps will not always show in the appropriate cell grid. Upon multiple clicks in the tile map space, your results may vary. (The rendering may or may not appear correctly) I've attached a gif demoing the behavior of the tile maps not rendering at all.
Expected: Tiles will "paint" (render) on click in the correct grid space.
There's no existing public thread on this issue, so head over toAnswerHub just mention UE-72279 in the post.