When adjusting properties from the details panel, if auto-key is off, animations will reset. In related cases, components can lose their binding, and their properties will turn red.
It may be that the spawnable was not spawned in time for the sequence to re-evaluate at that frame, and apply the animations.
When the change is committed, the actor will revert to the default pose.
When auto-key is on, or when changing the value from the timeline UI the animation pose remains correct.
Additionally moving the actor through the editor viewport will cause the animation to revert, but moving one of the components, like the root component, will not.
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-101261 in the post.