Moving a SmartObject inside of the level shows that the slot debug view is moved along with the SmartObject, but when PIEing the AI react as if it has not been moved/rotated. You must click Rebuild Collection on the SmartObjectCollection actor in the Outliner for the changes to take effect in the level.
Expected Result: AI runs to the new SmartObject location where the slot debug is drawn
Actual Result: AI runs to the original SmartObject location.
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-161576 in the post.