There is an issue that occurs where changing the scalability settings via the game script during play saves the values for the editor, but when the game is played a second time, the settings visually revert but then do not change when the script. This issue is not a regression.
Versions Tested: Issue occurs in all versions
4.16.3 - CL: 3561208
4.17.2 - CL: 3658906
4.18P2 - CL: 3660543
Head over to the existingAnswerHub thread and let us know what's up.