Changing levels with ClientTravel() breaks ability to activate sequence.
Client Travel API:
[Link Removed]
Confirmed in 4.22 MAIN at CL 4503321
Sample Project Attached
Result: After transitioning to the second level, you are unable to activate the sequence.
Workaround: Playing in Standalone functions as expected
There's no existing public thread on this issue, so head over to Questions & Answers just mention UE-65829 in the post.