It appears to be an issue with persistence and the sequencer.
The Level Sequence is ok as the tracks are all fine on reload. it's really because the Tube001 StaticMeshActor is no longer child of DatasmithSceneActor on reload.
You can even open and close the sequencer and then save the level. The hierarchy will be messed up on when reloading the level.
SEE: The object Tube001 is no longer in the original hierarchy and subsequent animation playback is broken.
A video showing the problem and models have been placed here:
There's no existing public thread on this issue, so head over toAnswerHub just mention UE-74252 in the post.